Nitesh Sule, Ph.D.

Dr. Nitesh Sule is a biochemist with training in enzymology, microfluidics, metabolomics and molecular microbiology, and extensive experience in method development and scientific writing. During his graduate work at the North Dakota State University, he elucidated the mechanisms of active-site specificity in metalloenzymes, identified potent inhibitors of antibiotic and anti-cancer drug targets, and explored the use of nanoparticle-conjugated enzymes as a tool for high-throughput screening, leading to several publications. As a postdoc at the Texas A&M University Engineering Experiment Station, Dr. Sule probed the role of the stress-hormone, norepinephrine, as a signaling molecule between gut microbiota and the host. He made a crucial connection between pathogen virulence in the small intestine and a microbiota-derived metabolite of norepinephrine. This work has opened a new avenue in the ongoing studies linking infections to stress. During this work, Dr. Sule developed a new microfluidic device designed to study bacterial chemotaxis. In a separate project for DARPA, Dr. Sule developed a new analytical method for extremely rapid and high-throughput analysis of soil metabolites, reducing the analysis time from days to under two hours. Dr. Sule has taught undergraduate courses in chemistry, microbiology and molecular biology. He has served as ad hoc reviewer for research articles and grant proposals, and as judge for high-school, undergraduate, graduate and postdoctoral science symposiums. When he is not working on proposals, he likes to spend his time entertaining his family, breaking things around the house, and getting lost outdoors.

Education: M.S. in Microbiology from University of Pune; Ph.D. in Biochemistry from North Dakota State University.