Webinar and Q&A

Presented by: Dana Upton, Ph.D.

Session Overview

In this webinar, Dr. Dana Upton from Eva Garland Consulting (EGC) explains the NSF SBIR/STTR program and how early-stage startups can use non-dilutive funding to potentially overcome the “valley of death” in R&D. It covers the program’s purpose, the differences between SBIR and STTR, the stages of funding from Project Pitch to Phase I and Phase II, and provides practical tips for creating competitive applications, managing grants, and building sustainable, innovative businesses.

Session Recap

  • Early-stage startups face a funding gap often referred to as the “Valley of Death,” where capital is scarce during critical R&D phases. 
  • Venture capital (VC) is highly selective; only a small percentage of startups receive early-stage VC funding. 
  • VC funding often favors specific sectors (software, telecom, internet) and geographies (California, Massachusetts), sometimes requiring relocation. 
  • The Valley of Death exists because critical R&D needs funds before commercial viability, a stage often overlooked by VCs. 

  • Non-dilutive funding (grants and contracts) provides capital without requiring equity or ownership transfer. 
  • The federal government allocates billions annually; SBIR/STTR programs total approximately $3 billion across 11 agencies. 
  • Benefits include the ability to fund multiple projects concurrently and improved survival rates; 99% of grant-funded companies are still operational after five years. 

  • VC funding is typically tied to one product and requires giving up some control or equity. 
  • Non-dilutive funding allows companies to retain control, pursue multiple innovations, and focus on sustainable growth. 
  • VC often favors established markets, while non-dilutive funding encourages high-risk, high-reward, innovative technologies. 

  • NSF has broader interests (e.g., non-medical robotics, AI, blockchain) compared to NIH’s medical focus. 
  • NSF Phase I budget is standardized ($305,000), while NIH budgets may vary by institute and project. 
  • NSF emphasizes commercialization strategy from Phase I onward; NIH focuses on scientific development and clinical research. 
  • NSF allows direct grant dollars for accounting; NIH requires indirect costs for similar activities. 
  • Payment structure differs: NSF disburses a lump sum upfront, while NIH operates on reimbursement via invoices. 

  • Designed to stimulate innovation, entrepreneurship, and private sector participation in federal R&D. 
  • Focuses on unproven, leading-edge technologies requiring intensive R&D. 
  • Requires developing a sustainable business and a product with potential to disrupt markets or create new ones. 

  • Project Pitch: Initial pre-application to demonstrate alignment with NSF mandate; submitted year-round; 3500 characters each for innovation and Phase I plan sections, and 1750 characters for market and company sections. 
  • Phase I Application: $305,000 for 12–18 months; includes 15-page project description, one-page summary, budget and justification, bios, synergistic activities, data management plan, IP rights agreement (for STTR), and letters of commitment. 
  • Phase II Application: $1.25 million; requires Phase I completion; includes 15 pages for Phase I final report, project description, and commercialization plan. 
  • Phase IIB Supplement: Additional funding (up to $0.5M) with cost matching; consult program director before applying. 
  • NSF review takes 3–6 months; pre-award negotiations involve technical and financial clarifications. 

  • Intellectual Merit: Novel, innovative research; not incremental improvements. 
  • Commercial Potential: Clear path to sustainable business and market impact. 
  • Societal Impact: Broad benefits including job creation. 
  • High-risk, high-reward projects encouraged, even at early feasibility stage. 

  • Read the NSF solicitation carefully and follow current rules. 
  • Start registrations early (SAM.gov, SBA, Research.gov). 
  • Seek expert guidance and feedback on the application. 
  • Tell a clear, compelling story using the seven C’s: complete, clear, concise, consistent, correct, considerate, convincing. 
  • Include figures to enhance clarity and engage reviewers. 
  • Understand your budget, including direct, indirect, and small business fee allocations. 

  • Confirm eligibility: US-based, for-profit, <500 employees, appropriate VC ownership. 
  • Assess readiness: Stage should be feasibility, refinement, or demonstration—not concept-only or near-commercialization. 
  • Clearly define innovation and competitive advantage. 
  • Map development path from current stage to envisioned final product. 
  • Integrate NSF funding into broader business strategy. 
  • Ensure sufficient time commitment for proposal preparation (estimates ~100 hours for Phase I). 

  • Non-Dilutive: No equity given up; maintain control of company, IP, and location. 
  • Founder-Friendly: Terms favor the entrepreneur, flexible use of funds. 
  • Expert Feedback: Reviewers and program directors provide guidance and coaching. 
  • Prestige: NSF award signals technical and commercial merit to investors. 
  • Financial Impact: Phase I and Phase II funding plus potential for follow-on VC and private investment. 

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